Table 2

Histological scoring of synovitis and cartilage changes in the tarsal joints from rats with adjuvant-induced arthritis

Group

Synovial structure (0–3)

Fibroplasia (0–3)

Inflammatory cells (0–3)

Pannus (0–2)

Total synovitis score (0–11)

T/MC vehicle

2.92 ± 0.21

2.67 ± 0.41

2.92 ± 0.21

2.00 ± 0.00

10.5 ± 0.63

WAY-169916, 0.3 mg/kg

2.33 ± 0.41*

2.33 ± 0.52

1.58 ± 0.38*

1.17 ± 0.75

7.42 ± 1.88*

WAY-169916, 0.1 mg/kg

2.17 ± 0.68*

1.92 ± 0.49*

1.50 ± 0.45*

0.83 ± 0.98*

6.42 ± 2.90*

Group

Cartilage structure (0–6)

Cartilage cells (0–3)

Safranin-O/Fast Green staining (0–4)

Tidemark integrity (0–1)

Total Mankin score (0–14)

T/MC vehicle

3.52 ± 0.42

2.33 ± 0.41

3.00 ± 0.00

0

8.58 ± 0.74

WAY-169916, 0.3 mg/kg

1.75 ± 0.69*

1.58 ± 0.38*

1.83 ± 0.41*

0

5.17 ± 1.77*

WAY-169916, 0.1 mg/kg

2.25 ± 0.42*

1.42 ± 0.49*

1.67 ± 0.41*

0

5.33 ± 1.21*

Results are means ± SD.

*Significantly less than vehicle (P < 0.005).

Keith et al. Arthritis Research & Therapy 2005 7:R427   doi:10.1186/ar1692