Table 1

Histological scoring of synovitis and cartilage damage in the tarsal joints from HLA-B27 transgenic rats

Group

Synovial structure (0–3)

Fibroplasia (0–3)

Inflammatory cells (0–3)

Pannus (0–2)

Total synovitis score (0–11)


T/MC vehicle

3.00 ± 0.00

2.80 ± 0.45

3.00 ± 0.00

1.60 ± 0.89

10.40 ± 1.34

WAY-169916, 10 mg/kg

1.80 ± 0.45*

1.20 ± 0.84*

1.40 ± 0.55*

0.40 ± 0.89

5.00 ± 2.24*

Prednisolone, 0.6 mg/kg

2.40 ± 0.55

2.00 ± 0.71*

2.00 ± 0.00*

1.60 ± 0.89

8.00 ± 1.87


Group

Cartilage structure (0–6)

Cartilage cells

Safranin-O/Fast Green staining (0–4)

Tidemark integrity (0–2)

Total Mankin score


T/MC vehicle

3.80 ± 0.84

2.80 ± 0.45

3.20 ± 0.45

0

9.80 ± 1.48

WAY-169916, 10 mg/kg

2.20 ± 0.45*

2.00 ± 0.45*

1.60 ± 0.55*

0

5.80 ± 0.84*

Prednisolone, 0.6 mg/kg

3.40 ± 0.55

2.20 ± 0.45*

3.00 ± 0.00

0

8.60 ± 0.89


Results are means ± SD.

*Significantly less than vehicle (P < 0.005). Significantly less than prednisolone (P < 0.005).

Keith et al. Arthritis Research & Therapy 2005 7:R427-R438   doi:10.1186/ar1692

Open Data