WAY-169916 inhibits the adjuvant-induced expression of serum acute-phase protein. Serum from control male rats or adjuvant-induced rats treated with either vehicle or WAY-169916 (5 mg/kg) was analyzed for the expression of (a) haptoglobin, (b) α1-acid glycoprotein (α1-AGP) or (c) C-reactive protein (CRP) by radial immunodiffusion assay. Results are expressed as means ± SEM from six rats per group. *P < 0.05 compared with vehicle control. CFA, complete Freund's adjuvant.
Keith et al. Arthritis Research & Therapy 2005 7:R427-R438 doi:10.1186/ar1692