WAY-169916 improves joint scores in a dose-dependent fashion in rat adjuvant-induced arthritis model. (a) Male Lewis rats were injected with complete Freund's adjuvant on day 1 and maximal inflammation was allowed to develop. Beginning on day 8 and continuing until day 22, rats were treated daily with oral vehicle or WAY-169916 (0.3 and 0.1 mg/kg). Joint scores were assessed by evaluating hindpaws for erythema and swelling (0 to 3 each; maximal score of 12). (b) WAY-169916 improves joint scores in rat adjuvant-induced arthritis model in both males and females. Experiments were performed as in (a) except that WAY-169916 was dosed daily at 5 mg/kg orally in both intact male and intact female rats.
Keith et al. Arthritis Research & Therapy 2005 7:R427 doi:10.1186/ar1692