WAY-169916 improves joint scores in HLA-B27 transgenic rat model of arthritis. HLA-B27 transgenic rats, 26 to 28 weeks old, presenting signs of arthritis were treated orally daily with vehicle, prednisolone (0.6 mg/kg), or WAY-169916 (10 mg/kg) for 29 days. Joint scores were assessed by evaluating hindpaws for erythema and swelling (0 to 3 each; maximal score of 12).
Keith et al. Arthritis Research & Therapy 2005 7:R427-R438 doi:10.1186/ar1692