Table 2

Concentrations of sTNFR1 and neuropeptides in serum

Variable

Early RA (pg/ml)

Long-standing RA (pg/ml)

P

Controls (pg/ml)


sTNFR1

1500a

1900b

ns

1200d

(1300–1700)

(1600–2000)

BN/GRP

3000a

1700b

<0.05

340e

(2400–3300)

(430–2500)

CGRP

1500a

820b

ns

310e

(1100–1600)

(510–1600)

NPY

610a

900c

ns

930f

(370–890)

(700–1900)

SP

170a

410b

<0.05

180g

(150–300)

(320–440)

VIP

250a

280b

ns

290g

(210–280)

(230–340)

ESR

20a

32b

ns

nm

(7 – 32)

(22 – 47)


Concentrations were measured using ELISA. Values are medians (and Q1–Q3). The ESR is also shown. P relates to long-standing RA versus early RA. an = 4; bn = 22; cn = 21; dsTNFR1 value in healthy controls according to the manufacturer; en = 4; fn = 2; gn = 11. BN/GRP, bombesin/gastrin-releasing peptide; CGRP, calcitonin-gene-related peptide; ESR, erythrocyte sedimentation rate; NPY, neuropeptide Y; nm, not measured; ns, not significant; RA, rheumatoid arthritis; SP, substance P; sTNFR1, soluble tumour necrosis factor receptor 1; VIP, vasoactive intestinal peptide.

Grimsholm et al. Arthritis Research & Therapy 2005 7:R416-R426   doi:10.1186/ar1503

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