Table 1

Cytokine and neuropeptide concentrations in synovial fluid

Substance

Early RA (pg/ml)

Long-standing RA (pg/ml)

P

Controls (pg/ml)


Cytokine

TNF-α

8.0a

7.0c

ns

nm

(1.0–47)

(1.0–24)

IL-6

5100b

3100d

<0.05

ndf

(4500–8000)

(1300–3900)

MCP-1

1200b

1500d

ns

620f

(810–1800)

(1200–3000)

Neuropeptide

BN/GRP

31a

17c

<0.05

ndg

(21–39)

(7.0–23)

CGRP

580b

450d

ns

ndf

(160–1500)

(230–960)

NPY

190b

260e

ns

180f

(65–320)

(170–500)

SP

48a

58c

ns

ndg

(36–80)

(42–77)

VIP

150b

300d

ns

nm

(40–200)

(55–630)


Concentrations were measured by ELISA and RIA in synovial fluid from the knee joints of patients with RA and in healthy control subjects. Values are medians (and Q1–Q3). P relates to long-standing RA versus early RA (Mann–Whitney test). an = 7; bn = 6; cn = 28; dn = 23; en = 25; fn = 2; gn = 10. BN/GRP, bombesin/gastrin-releasing peptide; CGRP, calcitonin-gene-related peptide; MCP-1, monocyte chemoattractant protein-1; nd, not detectable; nm, not measured; NPY, neuropeptide Y; ns, not significant; RA, rheumatoid arthritis; SP, substance P; TNF, tumour necrosis factor; VIP, vasoactive intestinal peptide.

Grimsholm et al. Arthritis Research & Therapy 2005 7:R416-R426   doi:10.1186/ar1503

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