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Commentary

Microsomal prostaglandin E synthase-1: the inducible synthase for prostaglandin E2

Annaleise V Sampey1, Seetha Monrad1 and Leslie J Crofford2*

Author Affiliations

1 University of Michigan, Ann Arbor, MI, USA

2 University of Kentucky, Lexington, KY, USA

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Arthritis Research & Therapy 2005, 7:114-117  doi:10.1186/ar1748

Published: 6 April 2005

Abstract

Microsomal prostaglandin E synthase-1 (mPGES-1) is an inducible enzyme that catalyzes the conversion of prostaglandin (PG)H2 to PGE2. Proinflammatory stimuli markedly increase levels of mPGES-1 expression both in vivo and in vitro. mPGES-1 knockout studies and animal models of inflammatory arthritis also provide a strong basis for the contribution of mPGES-1 in the increased local production of PGE2 observed in inflammatory arthritis. The focus of this article is to review some recent advances in our understanding of mechanisms specific to the regulation of inducible mPGES-1 in inflammatory arthritis.