Microsomal prostaglandin E synthase-1: the inducible synthase for prostaglandin E2

doi:10.1186/ar1748

Arthritis Research & Therapy

Volume 7
Issue 3

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Commentary

Microsomal prostaglandin E synthase-1: the inducible synthase for prostaglandin E₂

Annaleise V Sampey¹, Seetha Monrad¹ and Leslie J Crofford²

¹University of Michigan, Ann Arbor, MI, USA

²University of Kentucky, Lexington, KY, USA

author email corresponding author email

Arthritis Research & Therapy 2005, 7:114-117doi:10.1186/ar1748


Published:	6 April 2005

Abstract

Microsomal prostaglandin E synthase-1 (mPGES-1) is an inducible enzyme that catalyzes the conversion of prostaglandin (PG)H₂to PGE₂. Proinflammatory stimuli markedly increase levels of mPGES-1 expression both in vivo and in vitro. mPGES-1 knockout studies and animal models of inflammatory arthritis also provide a strong basis for the contribution of mPGES-1 in the increased local production of PGE₂observed in inflammatory arthritis. The focus of this article is to review some recent advances in our understanding of mechanisms specific to the regulation of inducible mPGES-1 in inflammatory arthritis.