Figure 2.

Structures of suppressor of cytokine signaling (SOCS) family molecules. CIS, Src homology 2 (SH2)-containing protein; EPO, erythropoietin; JAB, JAK (Janus family kinase)-binding protein; KIR, kinase inhibitory region; NAP4, Nck/Ash-binding protein 4; SSI-1, STAT (signal transducer and activator of transcription)-induced STAT inhibitor-1.