Joint inflammation in arthritic knee joints of C57Bl/6 mice injected with AxCANI (adenovirus encoding no gene) or AxCAhIL-13 (adenovirus encoding interleukin-13). At (a) day 3 and (b) day 7 after the onset of immune-complex-mediated arthritis. The inflammatory cell mass was significantly enhanced by IL-13 in both the joint cavity and the synovium 3 days after arthritis induction. Bars show the means ± SEM for 10 mice. Significance was evaluated using the Mann–Whitney U test. *P < 0.05.
Nabbe et al. Arthritis Res Ther 2005 7:R392 doi:10.1186/ar1502