Table 2

Clinical comparison of patients with rheumatoid arthritis (RA) expressing high* and low levels of survivin

Survivin high, erosive RA (n = 27)
 P
 Survivin low, erosive RA (n = 61)
 P
 Survivin low, non-erosive RA (n = 42)†
Survivin levels (pg/ml)




     Blood
 1180 ± 309
 <0.0001
 97 ± 9
 0.013
 127 ± 5
     Synovial fluid
 1039 ± 523
 0.016
 132 ± 4
 n.s.
 124 ± 2
Disease duration (years)
 15.5 ± 2.4
 n.s.
 13.6 ± 1.2
 0.0002
 8.3 ± 1.4
Age (years)
 58 ± 3
 n.s.
 60 ± 2
 0.05
 53 ± 3
Rheumatoid factor-positive (n)
 25
 n.s.
 53
 <0.0001
 10
C-reactive protein (mg/l)
 45 ± 9
 0.035
 29 ± 5
 n.s.
 39 ± 7
White blood cell count (× 109/ml)




     Blood
 8.7 ± 0.6
 0.038
 7.2 ± 0.3
 n.s.
 7.1 ± 0.3
     Synovial fluid
 10.8 ± 1.9
 n.s.
 11.2 ± 2.9
 n.s.
 13.1 ± 2.8

Continuous parameters are presented as the mean ± standard error of the mean. n.s., not significant. *Level of survivin above 300 pg/ml was considered 'high'. †One patient having a high survivin level is excluded.

Bokarewa et al. Arthritis Res Ther 2005 7:R349   doi:10.1186/ar1498

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