Table 2 |
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|
Changes in classification determined by multilevel salivary gland biopsies for Sjögren's syndrome (SS) |
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|
Test results and diagnostic accuracy |
FSa = 0 |
0 < FS < 1 |
1 ≤ FS < 2 |
FS ≥ 2 |
Total |
|
|
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|
No. of patients |
57 |
11 |
15 |
37 |
120 |
|
AECG classification changes |
0 |
0 |
6 (40°%) |
1 (3%) |
7 |
|
Baseline sensitivity (95% CI) |
85.7% (42.2–97.6) |
- |
100% (62.9–100) |
94.1% (80.3–99.1) |
93.9% (83.1–98.6) |
|
Revised sensitivity (95% CI) |
85.7% (42.2–97.6) |
- |
100% (62.9–100) |
94.1% (80.3–99.1) |
93.9% (83.1–98.6) |
|
Baseline specificity (95% CI) |
98% (89.3–99.7) |
- |
0%b (0–41.1) |
33.3%b (5.5–88.4) |
84.5% (74.0–92.0) |
|
Revised specificity (95% CI) |
98% (89.3–99.7) |
- |
85.7% (42.2–97.6) |
66.7% (11.6–94.5) |
94.4% (86.2–98.4) |
|
|
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|
aThe focus score (FS) is the number of inflammatory infiltrates of at least 50 cells present in 4 mm2 of salivary gland area. bVery low specificity is due to the absence (1 ≤ FS < 2) or extremely low number (FS ≥ 2) of patients classified as non-SS according to AECG criteria. AECG: American-European Consensus Group; CI: confidence interval; -, could not be evaluated with the available data. |
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|
Morbini et al. Arthritis Res Ther 2005 7:R343 doi:10.1186/ar1486 |
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