Table 1

Demographic, biopsy, and clinical data for 120 patients given salivary gland biopsies for Sjögren's syndrome (SS)

Clinical and laboratory parameters

FSa = 0

0 < FS < 1

1 ≤ FS < 2

FS ≥ 2


No. of patients

57

11

15

37

Sex

9M/48F

1 M/10 F

0 M/15 F

3 M/34 F

Age (years)

46 ± 12

46 ± 11

54 ± 14

56 ± 13

Baseline biopsy area (mm2)

6.1 ± 5.6

8.3 ± 2.8

8.6 ± 4.3

4.7 ± 2.6

Cumulative area of three biopsies (mm2)

17.1 ± 15.1

21.8 ± 9.3

22.6 ± 12.7

12.9 ± 6.4

Findings [No. (%)]

Dry eyes

49 (86)

9 (81)

14 (93)

33 (89)

Xerostomia

45 (79)

7 (63)

14 (93)

35 (94)

Positive Schirmer's test

24 (42)

4 (36)

9 (60)

18 (51)

Reduced salivary flow rate

30 (53)

7 (63)

13 (86)

34 (91)

Antinuclear antibodies

29 (51)

8 (73)

8 (53)

31 (83)

Ro/SS-A

18 (31)

3 (27)

6 (40)

25 (67)

La/SS-B

3 (5)

0

3 (20)

10 (27)

Rheumatoid factor

27 (47)

5 (45)

7 (46)

33 (89)

SS according to AECG criteria [No. (%)]

7 (12)

1 (9)

15 (100)

34 (92)

SS according to clinical re-evaluation [No. (%)]

7 (12)

0 (0)

8 (53)

34 (92)


aThe focus score (FS) is the number of inflammatory infiltrates of at least 50 cells present in 4 mm2 of salivary gland area. AECG, American-European Consensus Group; F, female; M, male; SS-A, anti-Ro60 antibodies; SS-B, anti-La antibodies.

Morbini et al. Arthritis Res Ther 2005 7:R343-R348   doi:10.1186/ar1486

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