|
Multivariate analysis of the factors associated with dispensation of selective COX-2 inhibitors versus traditional nonselective NSAIDs |
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| Crude OR (95% CI) |
Adjusted OR (95% CI) |
|
|
|
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| Age group (years) |
||
| 75+ |
3.17 (3.01–3.34) |
4.22 (3.95–4.51) |
| 55 to ≤74 |
2.86 (2.74–2.99) |
3.23 (3.06–3.40) |
| 18–54 |
Reference |
Reference |
| Female sex |
1.61 (1.52–1.66) |
1.52 (1.45–1.58) |
| Income level (lower) |
0.72 (0.68–0.76) |
0.90 (0.85–0.96) |
| Prior diagnosis of gastropathy |
1.93 (1.75–2.11) |
1.21 (1.08–1.36) |
| Prior gastrointestinal procedures |
1.94 (1.71–2.22) |
1.09 (0.94–1.27) |
| Prior dispensation of gastroprotective agents |
2.37 (2.25–2.50) |
1.57 (1.47–1.67) |
| Prior referral to gastroenterologist |
1.89 (1.69–2.12) |
1.23 (1.08–1.39) |
| Prior history of NSAID use |
||
| Recent, first time |
2.39 (2.14–2.66) |
2.17 (1.93–2.43) |
| Recent, chronic |
1.58 (1.46–1.70) |
1.21 (1.11–1.32) |
| >1 to 3 months |
1.12 (1.06–1.19) |
0.95 (0.89–1.01) |
| >3 to 12 months |
0.93 (0.88–0.98) |
0.84 (0.80–0.89) |
| No use in past year |
Reference |
Reference |
| Corticosteroids |
1.72 (1.62–1.82) |
1.16 (1.07–1.24) |
| Anticoagulants |
2.53 (2.15–2.98) |
1.56 (1.32–1.85) |
| Antidepressants |
1.69 (1.59–1.80) |
1.37 (1.28–1.46) |
| Benzodiazepines |
1.87 (1.78–1.95) |
1.20 (1.14–1.26) |
| Acetaminophen |
1.85 (1.76–1.94) |
1.41 (1.34–1.49) |
| Low dose ASA |
0.85 (0.81–0.89) |
0.56 (0.52–0.59) |
| Chronic Disease Score |
||
| 10+ |
2.88 (2.65–3.14) |
1.26 (1.13–1.41) |
| 5–9 |
2.21 (2.10–2.32) |
1.28 (1.20–1.37) |
| 1–4 |
1.88 (1.80–1.97) |
1.26 (1.19–1.33) |
| 0 |
Reference |
Reference |
| Specialist (versus GP) |
0.99 (0.94–1.04) |
0.89 (0.84–0.94) |
| Dosage |
||
| High dose |
1.91 (1.80–2.03) |
2.19 (2.06–2.33) |
| Low dose |
0.40 (0.38–0.42) |
0.29 (0.27–0.30) |
| Standard dose |
Reference |
Reference |
| Time period |
||
| January–June |
0.72 (0.68–0.76) |
0.54 (0.51–0.57) |
| July–Sept |
1.02 (0.95–1.09) |
0.99 (0.92–1.06) |
| October–December |
Reference |
Reference |
|
All covariables included simultaneously in the models are listed in this table; models were not adjusted for any other factors. ASA, acetylsalicylic acid; CI, confidence interval; COX, cyclo-oxygenase; GP, general practitioner; NSAID, nonsteroidal anti-inflammatory drug; OR, odds ratio. | ||
Moride et al. Arthritis Res Ther 2005 7:R333 doi:10.1186/ar1488 |
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