Table 2

Transmission disequilibrium test analysis of the US and UK systemic onset juvenile rheumatoid arthritis families using Transmit

Arg260 transmission

Thr260 transmission


SoJRA families

n

Observed

Expected

Observed

Expected

χ2 (1 df)

P


US only

82

99

(88.0)

65

(75.9)

6.0*

0.01*

US unaffected siblings

79

82

(77.5)

76

(80.5)

1.04

0.3

UK only

74

91

(89.0)

57

(58.0)

0.08

0.78

UK and US together

156

190

(177.8)

122

(134.2)

4.2*

0.04*


*Significant findings. n, number of informative families for transmission; UK, British Paediatric Rheumatology Study Group cohort; US, Cincinnati cohort.

Bukulmez et al. Arthritis Res Ther 2005 7:R285-R290   doi:10.1186/ar1480

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