|
Table showing genes which were upregulated or downregulated in osteoarthritic chondrocytes (changes in mRNA expression levels >2-fold; P < 0.01) |
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| Downregulated genes |
GenBank accession no. |
OA:N |
OA |
N |
Upregulated genes |
GenBank accession no. |
OA:N |
OA |
N |
|
|
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| CHI3L1 |
NM_001276 |
0.02 |
0.001 |
0.05 |
COMP |
NM_000095 |
2.07 |
19.93 |
10.68 |
| Follistatin |
NM_006350 |
0.06 |
0.01 |
0.22 |
BGLAP |
X53698 |
2.18 |
0.13 |
0.07 |
| APOD |
NM_001647 |
0.08 |
1.10 |
15.68 |
TIMP1 |
X03124 |
2.20 |
12.18 |
6.34 |
| EDR2 |
NM_004427 |
0.09 |
0.09 |
0.86 |
ARGBP2 |
AF049884 |
2.25 |
0.11 |
0.04 |
| MMP3 |
X05232 |
0.09 |
1.04 |
10.28 |
FGF18 |
AF075292 |
2.35 |
0.40 |
0.16 |
| Tob1 |
NM_005749 |
0.14 |
0.12 |
0.96 |
Fibronectin |
M10905 |
2.36 |
19.08 |
9.46 |
| SLC3A2 |
NM_002394 |
0.19 |
0.04 |
0.22 |
Frizzled homolog 1 |
NM_003505 |
2.37 |
0.05 |
0.03 |
| MAPK7 |
NM_002749 |
0.22 |
0.01 |
0.05 |
Choriolysin h 2 |
AA829685 |
2.38 |
0.06 |
0.03 |
| SOX9 |
Z46629 |
0.26 |
0.29 |
1.14 |
CRTL1 |
NM_001884 |
2.43 |
0.76 |
0.31 |
| SERPING1 |
NM_000062 |
0.27 |
0.76 |
3.27 |
MKP-L |
NM_007026 |
2.57 |
0.32 |
0.11 |
| TGFBR3 |
NM_003243 |
0.27 |
0.05 |
0.15 |
THBS3 |
NM_007112 |
2.59 |
0.11 |
0.04 |
| FRZB |
NM_001463 |
0.27 |
0.23 |
1.43 |
ADAMTS2 |
NM_014244 |
2.68 |
0.06 |
0.02 |
| MRS3/4 |
AF327402 |
0.28 |
0.12 |
0.43 |
ADAMTS1 |
NM_006988 |
2.70 |
0.12 |
0.05 |
| UBC |
M26880 |
0.31 |
3.29 |
11.04 |
CHM-I |
NM_007015 |
2.88 |
0.36 |
0.09 |
| Integrin α5 |
NM_002205 |
0.35 |
0.36 |
1.17 |
MMP-13 |
X75308 |
2.88 |
0.13 |
0.06 |
| GNB2L1 |
NM_006098 |
0.38 |
1.15 |
2.39 |
COL6A1 |
X15880 |
2.89 |
9.55 |
2.94 |
| NF-κB_p65 |
Q04206 |
0.40 |
0.04 |
0.10 |
COL11A1 |
J04177 |
3.84 |
0.52 |
0.16 |
| Pim-1 |
Z58595 |
0.41 |
0.05 |
0.15 |
TNFAIP6 |
NM_007115 |
4.73 |
0.33 |
0.07 |
| NCK1 |
NM_006153 |
0.41 |
0.01 |
0.04 |
Thrombospondin 2 |
NM_003247 |
5.01 |
0.13 |
0.03 |
| GSS |
NM_000178 |
0.43 |
0.03 |
0.06 |
COL2A1 |
X16468 |
5.67 |
11.62 |
2.20 |
| HLA-B |
M81798 |
0.43 |
1.43 |
3.50 |
SPP1 |
NM_000582 |
5.78 |
1.96 |
0.38 |
| ICAM1 |
NM_000201 |
0.44 |
0.09 |
0.26 |
CKTSF1B1 |
NM_013372 |
5.89 |
0.06 |
0.01 |
| TG-interacting factor |
NM_003244 |
0.47 |
0.05 |
0.10 |
COL6A3 |
NM_004369 |
8.70 |
3.49 |
0.45 |
| Phosphomannomutase 1 |
U86070 |
0.47 |
0.11 |
0.26 |
COL1A2 |
X55525 |
14.25 |
4.21 |
0.33 |
| DLX5 |
NM_005221 |
0.47 |
0.04 |
0.08 |
TGFBI |
NM_000358 |
14.67 |
2.41 |
0.18 |
| Biglycan |
NM_001711 |
0.49 |
0.21 |
0.50 |
COL3A1 |
X14420 |
31.33 |
15.33 |
0.52 |
| TP53 |
NM_000546 |
0.50 |
0.14 |
0.34 |
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|
N, mean of mRNA expression levels in the normal cartilage samples (in arbitrary units); OA, mean of mRNA expression levels in the osteoarthritic cartilage samples (in arbitrary units); OA:N, ratio of osteoarthritic to normal. | |||||||||
Gebauer et al. Arthritis Res Ther 2005 7:R274 doi:10.1186/ar1479 |
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