Table 2

Table showing genes which were upregulated or downregulated in osteoarthritic chondrocytes (changes in mRNA expression levels >2-fold; P < 0.01)

Downregulated genes

GenBank accession no.

OA:N

OA

N

Upregulated genes

GenBank accession no.

OA:N

OA

N


CHI3L1

NM_001276

0.02

0.001

0.05

COMP

NM_000095

2.07

19.93

10.68

Follistatin

NM_006350

0.06

0.01

0.22

BGLAP

X53698

2.18

0.13

0.07

APOD

NM_001647

0.08

1.10

15.68

TIMP1

X03124

2.20

12.18

6.34

EDR2

NM_004427

0.09

0.09

0.86

ARGBP2

AF049884

2.25

0.11

0.04

MMP3

X05232

0.09

1.04

10.28

FGF18

AF075292

2.35

0.40

0.16

Tob1

NM_005749

0.14

0.12

0.96

Fibronectin

M10905

2.36

19.08

9.46

SLC3A2

NM_002394

0.19

0.04

0.22

Frizzled homolog 1

NM_003505

2.37

0.05

0.03

MAPK7

NM_002749

0.22

0.01

0.05

Choriolysin h 2

AA829685

2.38

0.06

0.03

SOX9

Z46629

0.26

0.29

1.14

CRTL1

NM_001884

2.43

0.76

0.31

SERPING1

NM_000062

0.27

0.76

3.27

MKP-L

NM_007026

2.57

0.32

0.11

TGFBR3

NM_003243

0.27

0.05

0.15

THBS3

NM_007112

2.59

0.11

0.04

FRZB

NM_001463

0.27

0.23

1.43

ADAMTS2

NM_014244

2.68

0.06

0.02

MRS3/4

AF327402

0.28

0.12

0.43

ADAMTS1

NM_006988

2.70

0.12

0.05

UBC

M26880

0.31

3.29

11.04

CHM-I

NM_007015

2.88

0.36

0.09

Integrin α5

NM_002205

0.35

0.36

1.17

MMP-13

X75308

2.88

0.13

0.06

GNB2L1

NM_006098

0.38

1.15

2.39

COL6A1

X15880

2.89

9.55

2.94

NF-κB_p65

Q04206

0.40

0.04

0.10

COL11A1

J04177

3.84

0.52

0.16

Pim-1

Z58595

0.41

0.05

0.15

TNFAIP6

NM_007115

4.73

0.33

0.07

NCK1

NM_006153

0.41

0.01

0.04

Thrombospondin 2

NM_003247

5.01

0.13

0.03

GSS

NM_000178

0.43

0.03

0.06

COL2A1

X16468

5.67

11.62

2.20

HLA-B

M81798

0.43

1.43

3.50

SPP1

NM_000582

5.78

1.96

0.38

ICAM1

NM_000201

0.44

0.09

0.26

CKTSF1B1

NM_013372

5.89

0.06

0.01

TG-interacting factor

NM_003244

0.47

0.05

0.10

COL6A3

NM_004369

8.70

3.49

0.45

Phosphomannomutase 1

U86070

0.47

0.11

0.26

COL1A2

X55525

14.25

4.21

0.33

DLX5

NM_005221

0.47

0.04

0.08

TGFBI

NM_000358

14.67

2.41

0.18

Biglycan

NM_001711

0.49

0.21

0.50

COL3A1

X14420

31.33

15.33

0.52

TP53

NM_000546

0.50

0.14

0.34


N, mean of mRNA expression levels in the normal cartilage samples (in arbitrary units); OA, mean of mRNA expression levels in the osteoarthritic cartilage samples (in arbitrary units); OA:N, ratio of osteoarthritic to normal.

Gebauer et al. Arthritis Res Ther 2005 7:R274-R284   doi:10.1186/ar1479

Open Data