Table 3

Distribution of chemokine receptors of synovial tissues from patients with juvenile idiopathic arthritis

Patient no.

Age (year)

Form

Pattern

CD3

CCR7

CXCR3

CCR5

Lining

Sublining

Aggregates

Lining

Sublining

Aggregates

Lining

Sublining

Aggregates

1

14

Oligo per.

Diffuse

+++

+

+++

NP

+++

+++

NP

+++

++

NP

2

19

Poly RF-

Diffuse

+

-

++

NP

+

+++

NP

+

-

NP

3

10

Oligo per.

T-B

++

-

+

++

+

++

++

++

+

-

4

12

Oligo ext.

T-B

+++

++

+++

+++

++

+++

+++

++

+

++

5

7

Poly RF-

T-B

++

-

-

+

++

+++

+++

+++

+

+

6

15

Poly RF-

GC

+++

-

+

++

+++

+++

+++

+++

+

-

Oligo per., persistent oligoarticular; oligo ext., extended oligoarticular; Poly RF-, polyarticular rheumatoid factor-negative; NP, not present; T-B, aggregates of T and B cells; GC, T and B cell aggregates with germinal centre (GC)-like reaction. Scoring: -, absence of positive cells in high-power field; +, 1–10 positive cells per high-power field; ++, 10–20 positive cells per high-power field; +++, more than 20 positive cells per high-power field (see also the Methods section). Lining, lining layer and superficial subintima; sublining, perivascular infiltrates in sublining layer; aggregates, T and B cell aggregates with or without GC-like reaction. All evaluations were performed in areas characterised by a clear lymphocyte (anti-CD3 and anti-CD4 positive cells) infiltration (see also the Methods section and Fig. 3).

Gattorno et al. Arthritis Res Ther 2004 7:R256   doi:10.1186/ar1485