Open Access Highly Accessed Research article

Gene expression profiling in murine autoimmune arthritis during the initiation and progression of joint inflammation

Vyacheslav A Adarichev1, Csaba Vermes1, Anita Hanyecz1, Katalin Mikecz1, Eric G Bremer2 and Tibor T Glant1*

Author Affiliations

1 Section of Biochemistry and Molecular Biology, Department of Orthopedic Surgery, Rush University Medical Center, Chicago, Illinois, USA

2 Children's Memorial Institute for Education and Research, Northwestern University, Chicago, Illinois, USA

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Arthritis Res Ther 2005, 7:R196-R207  doi:10.1186/ar1472

Published: 14 December 2004

Additional files

Additional File 1:

A table (Excel file) that lists all information about the 37 genes differentially expressed (more than twofold level) in pre-arthritic joints/paws, when compared with the same genes expressed in normal (naive) joints/paws of BALB/cSCID mice (PA/AN comparison). The pre-arthritic (still non-inflamed) joints were collected within 24–48 hours after the onset of inflammatory symptoms in BALB/cSCID mice with adoptively transferred PGIA. Acutely inflamed paws from these arthritic BALB/cSCID mice were used as acute arthritic (AA) samples (the list of gene expression profiles is provided in 2.)

Format: XLS Size: 29KB Download file

This file can be viewed with: Microsoft Excel Viewer

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Additional File 2:

This file contains information about 256 upregulated and 21 downregulated genes in acutely arthritic joints/paws in five independent hybridization experiments. All genes with twofold or higher expression levels are listed.

Format: XLS Size: 121KB Download file

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Additional File 3:

This file includes 201 upregulated and 217 downregulated genes in subacute/chronic phase of arthritis (8–12 days after onset) with the corresponding information. The gene expression levels (twofold or higher) are compared with those expressed in normal joints of naive (absolutely negative) BALB/cSCID mice.

Format: XLS Size: 151KB Download file

This file can be viewed with: Microsoft Excel Viewer

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