Table 3

Up- and down-regulated genes in osteoarthritis (OA) fibroblast-like synoviocytes (FLSs) stimulated with protein I/II. Confluent OA FLSs were stimulated with protein I/II for 4 hours or left untreated as controls. Total RNA was isolated, reverse-transcribed into 32P-labeled cDNA, and hybridized to Atlas human cancer cDNA expression arrays. The values are expression ratios (protein I/II / control).


OA patient


Protein product of gene
 GenBank accession no.
 1
 2
 3a
Up-regulated



IL-6
 X04602
 3.0
 3.8
 6.8
Interferon-gamma receptor β subunit
 U05875
 5.8
 -
 7.7
Interferon regulatory factor 1
 X14454
 -
 11.0
 5.5
Leukemia inhibitory factor
 X13967
 4.1
 -
 5.0
Matrix matalloproteinase 3
 X05232
 -
 -
 13.3
Placenta growth factors 1+2
 X54936
 -
 -
 4.6
Glia maturation factor β
 M86492
 -
 -
 4.5
Transforming growth factor β2
 M19154
 -
 -
 4.5
Growth inhibitory factor
 D13365
 -
 -
 3.4
Rho-related GTP-binding protein RhoE
 X95282
 -
 -
 3.2
Vascular endothelial growth factor receptor 1
 X51602
 -
 -
 3.2
Collagen VI α3 subunit
 X52022
 -
 -
 3.2
Early growth response protein 1
 X52541
 -
 -
 3.0
TRK-T3
 X85960
 -
 -
 3.0
Down-regulated



Vimentin
 X56134
 -
 0.3
 -
Transmembrane protein SEX
 X87852
 -
 0.3
 -
Integrin β8
 M73780
 -
 0.3
 -

aClinical investigations revealed that, besides OA, patient 3 (results in bold type) also had RA.

Zeisel et al. Arthritis Res Ther 2005 7:R118   doi:10.1186/ar1462

Open Data