Table 1

Up-regulated genes in rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLSs) stimulated with protein I/II. Confluent RA FLSs were stimulated with protein I/II for 4 hours or left untreated as controls. Total RNA was isolated, reverse-transcribed into 32P-labeled cDNA, and hybridized to Atlas human cancer cDNA expression arrays. The values are expression ratios (protein I/II/ control).


RA patient


Protein product of gene
 GenBank accession no.
 1
 2
 3
Matrix metalloproteinase 3
 X05232
 5.0
 190.3
 6.0
IL-6
 X04602
 14.6
 65.0
 4.0
Leukemia inhibitory factor
 X13967
 10.8
 15.9
 5.0
Interferon regulatory factor 1
 X14454
 9.4
 15.3
 3.4
Fibroblast growth factor-5
 M37825
 3.5
 2.9
 5.7
CDC27Hs protein
 U00001
 7.4
 -
 10.6
Interferon gamma antagonist
 A25270
 5.4
 -
 13.0
Integrin αE
 L25851
 3.9
 -
 3.5
Vimentin
 X56134
 3.2
 -
 3.7
Transmembrane protein SEX
 X87852
 3.8
 -
 3.0
TRK-T3
 X85960
 -
 -
 7.3
Collagen I α2 subunit
 X55525
 5.7
 -
 -
Transforming growth factor β2
 M19154
 -
 -
 4.8
Cell division protein kinase 4
 M14505
 4.7
 -
 -
Bone morphogenetic protein 2A
 M22489
 -
 4.5
 -
Rho-related GTP-binding protein RhoE
 X95282
 4.3
 -
 -
Cyclin H
 U11791
 4.3
 -
 -
Tyrosine-protein kinase receptor UFO
 M76125
 3.9
 -
 -
Tissue inhibitor of metalloproteinase 1
 X03124
 3.9
 -
 -
BIGH3
 M77349
 3.8
 -
 -
Ras-related C3 botulinum toxin substrate 1
 M29870
 3.6
 -
 -
Transforming protein RhoA H12
 L25080
 3.5
 -
 -
CD9 antigen
 M38690
 3.5
 -
 -
Notch homolog
 M99437
 3.4
 -
 -
Integrin β8
 M73780
 3.4
 -
 -
Secreted protein acidic and rich in cysteine
 J03040
 3.2
 -
 -
α2-Macroglobulin receptor
 X13916
 3.1
 -
 -
Fibronectin 1
 X02761
 3.0
 -
 -

-, not found or <3.0.

Zeisel et al. Arthritis Res Ther 2005 7:R118   doi:10.1186/ar1462

Open Data