Table 3

Upregulated genes (Delta > 5, P < 0.01) not previously reported to be associated with arthritis

Accession no.

Gene

Delta

Rat CL

Rat QTLs

Human CL

Human QTLs

NM_178144

AMIGO3

Nd/Nd/5.9

8q32

Cia6

3p21.31

Asthma

NM_130411

CORO1A

3.1/2.7/6.6

1q36

Pia11

16p12.1

Blau syndrome, asthma

NM_024381

GYK

6.7/Nd/Nd

Xq22

Cia19

Xp21.3

Allergic rhinitis

NM_031670

KDAP

18.8/6.6/48.2

1q22

_

19q13.3

Asthma, SLE, MS, SD

NM_569105

LCP2

2.6/3.3/6.2

10q12

Cia16, Pia15

5q33.1

RA, PDB, asthma, IBD, psoriasis, ATD

NM_021586

LTBP2

Nd/Nd/6.5

6q31

Pia3, Pia24

14q24

SLE, MODY3

NM_198746

Ly-49.9

Nd/2.0/5.6

4q42

Cia13, Cia24, Pia7, Pia23, Oia2, Oia7, Oia8, Ciaa4

12p13-p12

RA, allergic rhinitis, hypophosphataemic rickets

NM_022667

MATR1

1.7/1.9/5.7

8q32

Cia6

3q21

Atopic dermatitis, asthma, psoriasis

NM_133306

OLR1

8.3/2.8/3.7

4q42

Cia13, Cia24, Pia7, Pia23, Oia2, Oia7, Oia8, Ciaa4

12p13.2-p12.3

RA, hypophosphataemic rickets, allergic rhinitis

NM_053687

SLFN4

5.8/4.6/4.8

10q26

Cia16, Cia21, Cia22, Cia23, Oia4, Ciaa2

17q11.2-q21.1

SLE, MS

The rat chromosomal location and the chromosomal locations of the corresponding human orthologue were identified and mapped to quantitative trait loci (QTLs) previously associated with inflammation, arthritis and/or other autoimmune diseases. Delta values are given for the following time points: day -13.8/day -13/day 3. ATD, autoimmune thyroid disease; CIA, type II collagen-induced arthritis; Ciaa, CIA autoantibody; CL, chromosome location; IBD, inflammatory bowel disease; MOYD 3, maturity-onset diabetes of the young 3; MS, multiple sclerosis; Nd, not differentially expressed; Oia, oil-induced arthritis; PDB, Paget's disease of bone; PIA, pristane-induced arthritis; RA, rheumatoid arthritis; SD, spondylocostal dysostosis; SLE, systemic lupus erythematosus.

Rioja et al. Arthritis Res Ther 2005 7:R101   doi:10.1186/ar1458