Table 1 |
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Clinical and pathological characteristics of different arthritis models in mice |
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Arthritis model |
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Characteristics |
Collagen-induced arthritis |
K/B×N arthritis |
G6PI-induced arthritis |
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Arthritogenic antigen |
Cartilage specific (CII) |
Systemic (G6PI) |
Systemic (G6PI) |
|
Susceptible strain |
DBA/1 |
KRN TCR transgenic × NOD F1 mice |
DBA/1 |
|
Arthritis induction |
CII immunization and boost |
Spontaneous |
G6PI immunization |
|
Pathogenic cells and effector mechanisms |
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T cells |
? |
Induction phase |
Induction and effector phases |
|
Antibodies |
Necessary and sufficient |
Necessary and sufficient |
Necessary |
|
FcγRI or FcγRIII necessary |
+ |
+ |
+ |
|
FcγRII |
+ |
+ or - in different studies |
+ |
|
C5 |
+ |
+ |
+ |
|
Mast cells |
Uncertain |
+ |
Unknown |
|
Neutrophils |
+ |
+ |
Unknown |
|
Macrophages |
Uncertain |
Unknown |
Unknown |
|
TNF-α |
+ |
(±) |
+ |
|
IL-1 |
+ |
+ |
Unknown |
|
IL-6 |
+ |
+ |
Unknown |
|
Spontaneous remission |
+ |
- |
+ |
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CII, type II collagen; G6PI, glucose-6-phosphate isomerase; TNF, tumor necrosis factor. |
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Kamradt and Schubert Arthritis Res Ther 2005 7:20 doi:10.1186/ar1476 |
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