Figure 1.

In situ hybridization analysis demonstrates large amounts of tumor necrosis factor (TNF) mRNA, in sites of bony remodeling in a patient with ankylosing spondylitis. TNF is a proinflammatory cytokine. Reproduced with permission from John Wiley & Sons, Inc. [16]. © 1995 American College of Rheumatology

Peloso and Braun Arthritis Res Ther 2004 6(Suppl 2):S36-S43   doi:10.1186/ar1012