Table 3

Discontinuation rates at 1 year for anti-TNF agents in randomized clinical trials

Trial

No. of patients

Patient characteristics

Regimens

Discontinuation rates (%)


ATTRACT [12]

428

Active RA despite methotrexate therapy; mean duration 9–12 years

Infliximaba

21

3 mg q 4 weeks

3 mg q 8 weeks

10 mg q 4 weeks

10 mg q 8 weeks

Placeboa (weekly)

50

ERA [14]

632

Early RA; mean duration <1 year (i.e. 11–12 months)

Etanercept

25 mg twice weekly

15

Methotrexate (mean, 19 mg) weekly

21


aAll groups also received methotrexate, mean 16–17 mg/week. ATTRACT, Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis With Concomitant Therapy; ERA, Early Rheumatoid Arthritis.

Yocum Arthritis Res Ther 2004 6(Suppl 2):S24-S30   doi:10.1186/ar997