Role of co-transferred type II collagen (CII)-specific T cells in collagen-antibody-induced arthritis. Incidence (a) and severity (b) of arthritis in different groups of age-matched male mutated mouse collagen (MMC)-positive and MMC-negative littermates (n = 7–11) that were injected with either monoclonal antibodies (day 0), T cells (107, day 1) or antibodies and T cells. All mice were monitored for the development of arthritis for 38 days and were included in the calculations. MMC-positive mice injected with antibodies were compared with mice co-transferred with antibodies and T cells. *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.005. The error bars in (b) indicate SEM.
Nandakumar et al. Arthritis Res Ther 2004 6:R544-R550 doi:10.1186/ar1217