Collagen-antibody-induced arthritis in mice deficient in B cells and T cells. Frequency (a) and severity (b) of arthritis in groups (n = 6–14) of B10.Q mice deficient in B cells (B KO), T cells (T KO), in both B and T cells (B KO+T KO) and wild-type littermate controls (WT). Mice were injected intravenously with 9 mg of monoclonal antibody cocktail on day 0. Another set of animals (n = 4–8) from each group were injected with PBS on day 0 as control. All the mice received lipopolysaccharide (25 μg per mouse) intraperitoneally on day 5. All the animals were scored for arthritis up to 1 month and were included in the calculations. None of the control mice developed arthritis. Mice deficient in B cells or T cells were compared with WT mice for statistical calculations. There was no significant difference in arthritis frequency and severity between B cell-deficient and T cell-deficient mice. The error bars in (b) indicate SEM.
Nandakumar et al. Arthritis Res Ther 2004 6:R544-R550 doi:10.1186/ar1217