Table 1 |
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The IL-17 superfamily: cellular sources, receptors, and major functions |
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| Cytokine |
Other names |
Cellular source |
Receptor |
Major functions |
|
|
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| IL-17 |
IL-17A, CTLA-8 |
T cells (memory) |
IL-17R (also known as, IL-17AR) |
Inflammation, neutrophil recruitment, cytokine secretion, bone metabolism |
| IL-17B |
Multiple organs |
IL-17BR (also known as, IL-17Rh1/Evi27) |
Cytokine secretion, inflammation |
|
| IL-17C |
Unknown |
Unknown |
Regulation of Th1 cytokines |
|
| IL-17D |
IL-27 |
Multiple organs |
Unknown |
Cytokine secretion |
| IL-17E |
IL-25 |
Th2 |
IL-17BR (also known as, IL-17Rh1/Evi27) |
Regulation of Th2 cytokines |
| IL-17F |
ML-1 |
CD4+ T cells and monocytes |
IL-17R? |
Angiogenesis, cytokine secretion, regulation of Th1 cytokines |
| HVS13 |
vIL-17 |
Herpesvirus saimiri infected cells |
IL-17R? |
Unknown (not required for cellular transformation) |
|
|
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References and further information on this family can be found in the report by Moseley and coworkers [24]. CTLA, cytotoxic T-lymphocyte associated antigen; IL, interleukin; IL-17R, interleukin-17 receptor; Th, T-helper. |
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Gaffen Arthritis Res Ther 2004 6:240 doi:10.1186/ar1444 |
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