Table 1

Serum IL-6, serum amyloid A and corticosterone during zymosan-induced arthritis in ob/ob and +/? mice

Time

IL-6 (pg/ml)

SAA (μg/ml)

Corticosterone (ng/ml)

+/?

ob/ob

+/?

ob/ob

+/?

ob/ob

Baseline

<39.0

<39.0

21.6 ± 2.6

25.3 ± 2.5

65.6 ± 15.0

140.6 ± 12.5^a

6 hours

518.0 ± 52.8

1034.1 ± 114.8^a

331.9 ± 14.8

191.8 ± 18.7^b

164.5 ± 15.9

216.3 ± 15.8^a

24 hours

85.7 ± 25.6

154.1 ± 59.2

456± 5 ± 23.4

810.6 ± 48.3^c

56.9 ± 8.5

149.4 ± 31.9^a

72 hours

<39.0

<39.0

30.9 ± 4.6

387.5 ± 48.8^c

70.3 ± 8.4

120.6 ± 19.3^a

7 days

ND

ND

36.4 ± 2.2

184.8 ± 56.5^a

ND

ND

14 days

ND

ND

131.8 ± 68.2

116.0 ± 30.1

ND

ND

Data shown represent means ± SEM of five to six mice per group. The results are representative of five independent experiments. Differences between groups were analyzed using one-way analysis of variance. ^aP < 0.05; ^bP < 0.0002; ^cP < 0.0001 for ob/ob versus +/? mice. ND, not done; SAA, serum amyloid A.

Bernotiene et al. Arthritis Res Ther 2004 6:R256   doi:10.1186/ar1174