The active metabolite of leflunomide, A77 1726, increases the production of IL-1 receptor antagonist in human synovial fibroblasts and articular chondrocytes

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Gaby Palmer, Danielle Burger, Françoise Mezin, David Magne, Cem Gabay, Jean-Michel Dayer and Pierre-André Guerne^*

* Corresponding author: Pierre-André Guerne Pierre-Andre.Guerne@medecine.unige.ch

Arthritis Res Ther 2004, 6:R181-R189 doi:10.1186/ar1157