Table 3

Correlations between histologically assessed cartilage erosion scores and markers of bone (CTX-I) and cartilage (CTX-II) turnover in the knees of female Sprague–Dawley rats

Changes in CTX-I

Changes in CTX-II



Cohorta (treatment)

Age at start (months)

From weeks 0–4

At week 4

From weeks 0–4

At week 4


A (OVX or shamb) (n = 18)

5

Cartilage erosion:

Total

0.10

0.15

0.50

0.27

Medial femur

0.47

-0.02

0.64*

0.51*

B (OVX or shamb) (n = 17)

7

Cartilage erosion:

Total

0.24

0.25

0.74**

0.54*

Medial femur

0.24

0.41

0.70**

0.63**

C (OVX + intervention or shamb) (n = 56)

5

Cartilage erosion:

Total

0.40**

0.34*

0.50***

0.43**

Medial femur

0.35*

0.33*

0.37**

0.45**


Values are Spearman's rho. aCohorts: A, see Table 1; B, see Table 1; C, intervention with either estrogen or SERM – see Table 2. bSham operation. *P < 0.05, **P < 0.01, ***P < 0.001. CTX-I, collagen type I fragments; CTX-II, collagen type II fragments.

Høegh-Andersen et al. Arthritis Res Ther 2004 6:R169-R180   doi:10.1186/ar1152

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