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Cytokine release from draining lymph node cells of collagen-induced arthritis mice |
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| Cytokine release from DLN cells |
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| Treatment |
IFN-γ (ng/ml): 48 hour CII |
IFN-γ (ng/ml): 48 hour ConA |
IL-4 (pg/ml): 48 hour CII |
IL-4 (pg/ml): 48 hour ConA |
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| GTRTEmpty + doxycycline |
0.41 ± 0.03 |
4.2 ± 1.1 |
11.9 ± 3.2 |
33.2 ± 8.8 |
| GTRTT – doxycycline |
0.66 ± 0.15 |
2.4 ± 0.8 |
6.4 ± 1.5 |
24.4 ± 6.7 |
| GTRTT + doxycycline |
0.49 ± 0.04 |
2.8 ± 0.9 |
9.0 ± 1.6 |
21.5 ± 2.4 |
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Results are presented from at least six animals in each group. Cytokine release from draining lymph node (DLN) cells was induced by 48 hours of stimulation with CII or ConA and was measured by ELISA. CII, collagen type II. | ||||
Gould et al. Arthritis Res Ther 2004 6:R103 doi:10.1186/ar1036 |
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