Table 1 |
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|
Anticollagen II antibodies in mice with collagen-induced arthritis |
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| Anti-CII antibodies |
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|
|
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| Treatment |
Total IgG1 |
IgG1 |
IgG2a |
IgG2a : IgG1 ratio |
|
|
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| GTRTEmpty + doxycycline |
0.64 ± 0.11 |
2.0 ± 0.7 |
1.6 ± 0.3 |
1.3 ± 0.4 |
| GTRTT – doxycycline |
1.1 ± 0.4 |
1.7 ± 0.5 |
1.5 ± 0.5 |
1.4 ± 0.3 |
| GTRTT + doxycycline |
1.1 ± 0.3 |
1.6 ± 0.3 |
1.3 ± 0.2 |
1.4 ± 0.4 |
|
|
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|
Results are presented from at least six animals in each group. Anti-CII IgG levels in sera collected at the end of the experiment (day 40) was determined by ELISA, with values expressed relative to those obtained for a pooled sample from untreated mice at the same time point. CII, collagen type II. |
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|
Gould et al. Arthritis Res Ther 2004 6:R103 doi:10.1186/ar1036 |
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