Table 4 |
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Genes that distinguish children with active juvenile rheumatoid arthritis in discriminant function analysis |
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|
Gene bank |
Name |
Description |
AverAD |
AverHC |
Partial Wilks λ |
Summary of function |
|
|
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|
M11147 |
FTL |
Ferritin L chain |
23.25 |
82.87 |
0.008 |
Ferritin light polypeptide; iron storage protein |
|
D23661 |
RPL37 |
Ribosomal protein L37 |
65.72 |
73.62 |
0.027 |
Ribosomal protein L37; component of the large 60-S ribosomal subunit |
|
M59907 |
GRANULOPHYSIN |
CD63 |
27.03 |
21.75 |
0.006 |
Melanoma-associated antigen; may function as a blood platelet activation marker |
|
M20681 |
SLC2A3P |
SLC2A3 glucose transporter |
26.23 |
29.56 |
0.004 |
Facilitated glucose transporter |
|
Y14737 |
HDC |
Immunoglobulin heavy constant γ3 |
22.24 |
56.99 |
0.002 |
Constant region of heavy chain of IgG3 |
|
U14747 |
VSNL1 |
VSNL1 |
22.05 |
12.47 |
0.174 |
Visinin-like protein 1; may bind calcium |
|
X02812 |
TGFB1 |
TGFB1 |
20.11 |
30.1 |
0.005 |
Transforming growth factor β1; regulates cell proliferation, differentiation, and apoptosis |
|
Y00787 |
IL-8 |
IL-8 |
19.36 |
54.2 |
0.018 |
Interleukin 8; cytokine that plays a role in chemoattraction and activation of neutrophils |
|
AF026939 |
RIGG |
IFNIT4 interferon-induced protein |
16.68 |
1.97 |
0.026 |
Interferon-induced protein |
|
X13403 |
OTF1 |
Octamer-binding protein Oct-1 |
15.46 |
14.96 |
0.005 |
Ubiquitously expressed POU homeodomain transcription factor 1 |
|
Y08110 |
SORLA |
Sortilin-related receptor |
14.48 |
28.66 |
0.002 |
Sortilin-related receptor; may be involved in the uptake of lipoproteins and proteases |
|
U75283 |
SR-BP1 |
Sigma receptor |
11.46 |
5.34 |
0.004 |
Type I sigma receptor; transmembrane protein that interacts with psychotomimetic drugs, including cocaine and amphetamines |
|
X02492 |
15-Jun |
Interferon-inducible fragment |
10.3 |
1.88 |
0.024 |
Induced by α and β interferon; hydrophobic |
|
M64722 |
APOJ |
Clusterin |
9.74 |
4.84 |
0.003 |
Clusterin, glycoprotein found in high-density lipoproteins and endocrine and neuronal granules; has a role in the terminal complement reaction |
|
M55646 |
IL1RN |
IL-1 receptor antagonist |
7.03 |
3.69 |
0.056 |
Interleukin 1 receptor antagonist; binds to and inhibits the IL-1 receptor |
|
X57198 |
TFIIS |
Transcription elongation factor A |
6.38 |
7.9 |
0.005 |
Transcription elongation factor A (SII); stimulates the activity of the RNA polymerase II elongation complex |
|
AF043233 |
HPECT1 |
Caco-2 oligopeptide transporter |
5.49 |
2.87 |
0.004 |
H(+)-coupled peptide transporter; absorbs small peptides produced by digestion of dietary proteins and may transport β-lactam antibiotics |
|
U26173 |
IL3BP1 |
Interleukin 3 regulated nuclear factor |
5.4 |
6.58 |
0.033 |
Basic leucine zipper (bZIP) transcription factor; activates IL3 gene expression and can also repress transcription; binds to regulatory sequences in the promoters of the adenovirus E4, γ interferon (IFNG), and interleukin 3 (IL3) genes |
|
X05997 |
Gastric lipase |
5.27 |
28.58 |
0.008 |
Digestion of dietary triglycerides in the gastrointestinal tract |
|
|
|
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|
AverAD, AverHC, average expression level (defined as the number of standard deviations from mean of background) in untreated patients with active disease and in healthy controls, respectively. The discriminative power of each gene can also be characterized by the partial Wilks λ coefficient. This value is equal to the ratio of within-group differences in expression to within- and between-group differences in expression. It ranges from 1.0 (no discriminatory power) to 0.0 (perfect discriminatory power). ND, none detected. |
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|
Jarvis et al. Arthritis Res Ther 2004 6:R15 doi:10.1186/ar1018 |
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