Table 2 |
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|
Effects of osteoprotegerin in animal models of arthritis |
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|
Kong et al. [36] |
Redlich et al. [14] |
Romas et al. [37] |
|
|
|
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|
Arthritis model |
Adjuvant arthritis |
hTNFtg |
Collagen-induced arthritis |
|
Species |
Rat |
Mouse |
Rat |
|
Dose |
1 mg/kg/day |
6.4 mg/kg/day |
3 mg/kg/day |
|
Start |
Onset of symptoms |
Onset of symptoms |
Onset of symptoms |
|
Duration |
7 days |
35 days |
5 days |
|
Effect on inflammation |
No |
No |
No |
|
Effect on cartilage damage |
Yes |
No |
Milda |
|
Effect on bone erosion |
Yes |
-56% |
-60% |
|
Effect on osteoclast count |
-85% |
-70%b,c |
-75%c |
|
Effect on osteoporosis |
Yes |
Yes |
Not assessed |
|
|
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|
a Effects limited to joints with mild inflammation. b Osteoclasts were counted in the synovial pannus. c Osteoclasts were assessed by histomorphometry of the juxtarticular trabecular bone. |
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Schett et al. Arthritis Res Ther 2003 5:239 doi:10.1186/ar990 |
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