Table 1 |
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|
Summary of in vivo imaging methodologies |
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| Imaging mode |
Invasiveness |
Sensitivity, resolution, time scale |
Advantages |
Disadvantages |
|
|
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| Bioluminescence |
Anesthesia |
~100 cells, 5 mm, minutes |
Noninvasive, sensitive, quantitative |
Resolution, penetration |
| Micro positron emission tomography/single photon emission commuted tomography |
Anesthesia |
1000 cells, 2 mm, minutes |
Noninvasive, resolution |
Short half-life of isotopes |
| Magnetic resonance imaging |
Anesthesia |
1000 cells, 0.1 mm, minutes |
Noninvasive, resolution |
Sensitivity, slow |
| Intravital microscopy |
Anesthesia/surgery |
1 cell, 0.2 μm, seconds |
Highest resolution |
Invasive, penetration limited |
|
|
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Dustin Arthritis Res Ther 2003 5:165 doi:10.1186/ar768 |
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