Table 4

Functional clustering of deregulated genes in the arthritic synovial fibroblasts

    Stress response

    Protein synthesis

DD(M34561) Hsp70

DDU89417) Ribosomal protein L3 (x3)

DD(AF170920) HSPC030

DD(X15013.1) Ribosomal protein L7a (x3)

DD(AA240130) EST~GMP reductase Reductase

MA(U93862) Ribosomal protein L41

DD(U93231.1) Aldose

MA(AA048927) Aminoacyl-tRNA synthetase

DD(NM010239) Ferritin heavy chain

DD(AF081140) Homologue to eIF6/integrin b4 int. prot.

    Energy production

MA(U63323) Translation initiation factor (Eif4g2)

DD,.MA(U53584) Mt DNA polymerase γ

MA(AA408104) Translational initiation factor (eIF-2) α

DD(M22756) NADH dehydrogenase S2

MA(AA254996) Alanyl-tRNA synthetase

DD(AF100726) NADH dehydrogenase S4

    Protein degardation

DD(AF058955) Succinyl-CoA synthetase β

MA(U19854) ubiquitinating enzyme E2-20K

DD(AF159396.1) Mt. Cytochrome b

MA(X97042) UBcM4

MA(X01756) Cytochrome c (MC1)

MA(AA198790)ubiquinol-cytochrome c reductase (6.4)

MA(U03283) C3H cytochrome P450 (Cyp1b1)

MA(AA237529)ubiquinol-cytochrome c reductase (7.2)

    Transcription

    Growth control

DD(NM007241) EAP330 of ELL

DD, MA(U42383) FIN 13

MA(U09138) PPAR γ2

MA(M65287) ActR

MA(M62867) MSY-1

MA(K01700) p53

MA(U20282) SPBP

MA(U28789) PACT

MA(D31966) RNA polymerase I 40 kDa subunit

MA(X59728) gas5

MA(X67083) Chop-10

MA(X54149) MyD118

MA(X61800) C/EBP δ

MA(L02914) Aquaporin

MA(X62940) TSC-22

MA(M86736) Acrogranin

MA(L03279) CBF

    ECM/Adhesion

MA(D43643) YL-1

MA(M15525) Laminin B1

    RNA processing

MA(M65287) ActR

DD(AB017020) HnRNP D-like/JKTBP (x2)

MA(L08235) Clusterin

MA(U11274) AUF1

DD(X040170) SPARC

MA(AA408185) SFRS7

MA(D14340) ZO-1

MA(X66091) ASF

DD(U75916) ZO-2

MA(L15447) Rnu1a-1

MA(X56123) Talin

MA(U48737) PRP4m

MA(L02918) procollagen type V alpha 2

MA(AF017153) mDEAH9

MA(J04694) α-1 type IV collagen

MA(X80232) SIG41

MA(J04695) α-2 type IV collagen

MA(U70315) U1 snRNP- C

MA(L29454) Fibrillin

    Calcium binding

MA(Z30970) TIMP-3

MA(M37761) Calcyclin

MA(AA184551) Cadherin-11

MA(D86214) Ca2+ dep. activated. Prot. for secretion

MA(D90362) CAP102/alpha catenin

MA(X83934) Ryanodine receptor type 3

    Antigen presentation

DD(X04017) SPARC

DD(M35244) MHC-1b H2-TL-T10-129

MA(U81829) Calumenin

MA(U10090) C57BL/6 Ly-49D-GE antigen

MA(L29454) Fibrillin

DD,MA(AF110520) MHC class II

    Cytoskeleton organization

DD(X04653) T-cells activating protein (TAP)

MA(L20509) Matricin

MA(U60087) TAP2-d

Nβ-actin

MA(X62742) Ma

DD(AF064236.1) Smoothelin large isoform L2

MA(U35323) H2-M α, H2-M β2, H2-M β1, Lmp2

MA(X56123) Talin

MA(U65636) beta proteasome subunit (Lmp3)

MA(Z31553) Cctz (Chaperonin containing TCP-1 β z)

MAU22031) 20S proteasome subunit (Lmp7)

MA(D49382) Nedd5 (Septin)

MA(L11613) proteasome (lmp2)

MA(W08453) Destrin

MA(D85561) proteasome subunit MECL1


Numbers in parentheses refer to accession numbers; superscript prefixes indicate the method of gene selection, as follows: DD, differential display; MA, microarrays; N, Northern blot. Shading denotes down-regulated genes.

Aidinis et al. Arthritis Res Ther 2003 5:R140-R157   doi:10.1186/ar749

Open Data