Table 4 |
|
|
Functional clustering of deregulated genes in the arthritic synovial fibroblasts |
|
|
Stress response |
Protein synthesis |
|
DD(M34561) Hsp70 |
DDU89417) Ribosomal protein L3 (x3) |
|
DD(AF170920) HSPC030 |
DD(X15013.1) Ribosomal protein L7a (x3) |
|
DD(AA240130) EST~GMP reductase Reductase |
MA(U93862) Ribosomal protein L41 |
|
DD(U93231.1) Aldose |
MA(AA048927) Aminoacyl-tRNA synthetase |
|
DD(NM010239) Ferritin heavy chain |
DD(AF081140) Homologue to eIF6/integrin b4 int. prot. |
|
Energy production |
MA(U63323) Translation initiation factor (Eif4g2) |
|
DD,.MA(U53584) Mt DNA polymerase γ |
MA(AA408104) Translational initiation factor (eIF-2) α |
|
DD(M22756) NADH dehydrogenase S2 |
MA(AA254996) Alanyl-tRNA synthetase |
|
DD(AF100726) NADH dehydrogenase S4 |
Protein degardation |
|
DD(AF058955) Succinyl-CoA synthetase β |
MA(U19854) ubiquitinating enzyme E2-20K |
|
DD(AF159396.1) Mt. Cytochrome b |
MA(X97042) UBcM4 |
|
MA(X01756) Cytochrome c (MC1) |
MA(AA198790)ubiquinol-cytochrome c reductase (6.4) |
|
MA(U03283) C3H cytochrome P450 (Cyp1b1) |
MA(AA237529)ubiquinol-cytochrome c reductase (7.2) |
|
Transcription |
Growth control |
|
DD(NM007241) EAP330 of ELL |
DD, MA(U42383) FIN 13 |
|
MA(U09138) PPAR γ2 |
MA(M65287) ActR |
|
MA(M62867) MSY-1 |
MA(K01700) p53 |
|
MA(U20282) SPBP |
MA(U28789) PACT |
|
MA(D31966) RNA polymerase I 40 kDa subunit |
MA(X59728) gas5 |
|
MA(X67083) Chop-10 |
MA(X54149) MyD118 |
|
MA(X61800) C/EBP δ |
MA(L02914) Aquaporin |
|
MA(X62940) TSC-22 |
MA(M86736) Acrogranin |
|
MA(L03279) CBF |
ECM/Adhesion |
|
MA(D43643) YL-1 |
MA(M15525) Laminin B1 |
|
RNA processing |
MA(M65287) ActR |
|
DD(AB017020) HnRNP D-like/JKTBP (x2) |
MA(L08235) Clusterin |
|
MA(U11274) AUF1 |
DD(X040170) SPARC |
|
MA(AA408185) SFRS7 |
MA(D14340) ZO-1 |
|
MA(X66091) ASF |
DD(U75916) ZO-2 |
|
MA(L15447) Rnu1a-1 |
MA(X56123) Talin |
|
MA(U48737) PRP4m |
MA(L02918) procollagen type V alpha 2 |
|
MA(AF017153) mDEAH9 |
MA(J04694) α-1 type IV collagen |
|
MA(X80232) SIG41 |
MA(J04695) α-2 type IV collagen |
|
MA(U70315) U1 snRNP- C |
MA(L29454) Fibrillin |
|
Calcium binding |
MA(Z30970) TIMP-3 |
|
MA(M37761) Calcyclin |
MA(AA184551) Cadherin-11 |
|
MA(D86214) Ca2+ dep. activated. Prot. for secretion |
MA(D90362) CAP102/alpha catenin |
|
MA(X83934) Ryanodine receptor type 3 |
Antigen presentation |
|
DD(X04017) SPARC |
DD(M35244) MHC-1b H2-TL-T10-129 |
|
MA(U81829) Calumenin |
MA(U10090) C57BL/6 Ly-49D-GE antigen |
|
MA(L29454) Fibrillin |
DD,MA(AF110520) MHC class II |
|
Cytoskeleton organization |
DD(X04653) T-cells activating protein (TAP) |
|
MA(L20509) Matricin |
MA(U60087) TAP2-d |
|
Nβ-actin |
MA(X62742) Ma |
|
DD(AF064236.1) Smoothelin large isoform L2 |
MA(U35323) H2-M α, H2-M β2, H2-M β1, Lmp2 |
|
MA(X56123) Talin |
MA(U65636) beta proteasome subunit (Lmp3) |
|
MA(Z31553) Cctz (Chaperonin containing TCP-1 β z) |
MAU22031) 20S proteasome subunit (Lmp7) |
|
MA(D49382) Nedd5 (Septin) |
MA(L11613) proteasome (lmp2) |
|
MA(W08453) Destrin |
MA(D85561) proteasome subunit MECL1 |
|
|
|
|
Numbers in parentheses refer to accession numbers; superscript prefixes indicate the method of gene selection, as follows: DD, differential display; MA, microarrays; N, Northern blot. Shading denotes down-regulated genes. |
|
|
Aidinis et al. Arthritis Res Ther 2003 5:R140 doi:10.1186/ar749 |
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