Table 1

Summary of arthritis induction by transfer of TNF-expressing SFs

Derived

Transgene

Clone

Host genotype

Incidence of arthritis

Synovium

hTNF/TAg

B2

wt

31/65 (47.6%)

Synovium

hTNF/TAg

B1

wt

5/8 (62.5%)

Synovium

hTNF/TAg

A4

wt

4/8 (50.0%)

Synovium

TAg

F6

wt

0/54

Synovium

TAg

B2

wt

0/8

Synovium

TAg

A2

wt

0/8

Synovium

hTNF/TAg + Ab^a

B2

wt

0/16

Synovium

hTNF/TAg

B2

RAG^-/^-

6/10 (60.0%)

Synovium

TAg

F6

RAG^-/^-

0/9

Lung^b

hTNF/TAg

LFs

wt

0/6

Lung^b

hTNF/TAg

LFs

RAG^-/^-

0/5

Mice were classified as arthritic upon positive confirmation by histological analysis. ^a+Ab denotes group injected with arthritogenic clone B2 and then treated with anti-hTNF antibody 2 weeks after injection. ^b 'Lung' refers to a population of hTNF-secreting lung fibroblasts derived from hTNF/TAg double transgenic mice. hTNF, human tumor necrosis factor; RAG, recombinant activating gene; TAg, large tumor antigen; wt, wild-type.

Aidinis et al. Arthritis Res Ther 2003 5:R140   doi:10.1186/ar749