Figure 4.

MMP1 and MMP9 are up-regulated in arthritic SF clone B2. RT-PCR of hTNF/TAg SF clone B2 and wt/TAg SF clone F6, as described in Materials and methods. F6/mTNF: wt/TAg SF clone F6 stably transfected with mouse TNF, acting as positive control. hTNF = human tumor necrosis factor; MMP = matrix metalloproteinase; RT-PCR = reverse transcriptase polymerase chain reaction; SF = synovial fibroblast; TAg = large tumor antigen; TNF = tumor necrosis factor; wt = wild-type.