Figure 1.

Naïve and memory CD4+ and CD8+ T-cell subpopulations in patients with rheumatoid arthritis (RA), patients with systemic lupus erythematosus (SLE), and healthy control individuals. (a) Representative flow cytometry showing naïve and memory subpopulations of CD4+ and CD8+ T cells from one RA patient and a sex- and age-matched control individual. (b) Pooled data showing naïve and memory subpopulations of CD4+ and CD8+ T cells from RA patients (n = 8) and control individuals (n = 8). Horizontal lines indicate means. (c) Pooled data showing naïve and memory subpopulations of CD4+ and CD8+ T cells from SLE patients (n = 12) and control individuals (n = 12). Horizontal lines indicate means. (d) The correlation between age and CD45RA+CD62L- terminally differentiated CD8+ T cells from control individuals (n = 13), RA patients (n = 8), and SLE patients (n = 12) is shown. The P values were calculated using Mann–Whitney U test and Student's t-test for panel b and linear regression for panel d.

Maldonado et al. Arthritis Res Ther 2003 5:R91-R96   doi:10.1186/ar619