Table 4

Sensitivity and specificity of Anti-Scl-70 in diagnosis of SSc

SSc versus:

Assay used

Sensitivity (%)

Specificity (%)

Normal controls

ID

20*

100*

IB

41*

99.4*

ELISA

43*

100*

Overall

34^†

99.6^†

Other connective tissue diseases

ID

26*

99.5*

IB

40*

99*

ELISA

43*

90*

Overall

97.9^†

Primary Raynaud's phenomenon

ID

28*

98*

Non-SSc relatives

ID

25.5*

100* ^†

*Reference [35]. ^†Reference [36]. ELISA, enzyme-linked immunosorbent assay; IB, immunoblotting; ID, immunodiffusion.

Ho and Reveille Arthritis Res Ther 2003 5:80   doi:10.1186/ar628