Table 3

Major histocompatibility complex class II associations with autoantibodies seen in patients with SSc

Autoantibodies

HLA association

Comments

References


ACA

HLA-DRB1

DRB1*01

In Hispanics and Caucasians

[53-55]

DRB1*04

HLA-DQB1

DQB1*05

[53,55]

Anti-Scl-70

HLA-DRB1

DRB1*1101

In Caucasians and African Americans

[53-55]

DRB1*1104

In Japanese

[53,55]

DRB1*1502

In Hispanics and Caucasians

[55,136]

HLA-DQB1

DQB1*0301

[71]

DQB1*0601

HLA-DPB1

DPB1*1301

In Caucasians

[55]

DPB1*0901

In Japanese

[136]

Anti-PM-Scl

HLA-DQA1*0501

Not seen in Japanese

[54,80]

HLA-DRB1*0301

Anti-Th/To

HLA-DRB1*11

[87]

Anti-RNAP

HLA-DQB1*0201 ?

[91,93]

No association

Anti-U1-RNP

HLA-DR2

In Japanese and Caucasians

[117]

HLA-DR4

HLA-DQw5

In African Americans

[118]

DQA1*0101

DQB1*0501

HLA-DQw8

DQB1*0302

Anti-U3-RNP/antifibrillarin antibodies

HLA-DQB1*0604 ?

[91,93]

No association


Question marks denote associations seen in one study but not confirmed elsewhere. ACA, anti-centromere antibodies; HLA, human leukocyte antigen; RNP, ribonucleoprotein.

Ho and Reveille Arthritis Res Ther 2003 5:80-93   doi:10.1186/ar628