Table 3 |
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Major histocompatibility complex class II associations with autoantibodies seen in patients with SSc |
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|
Autoantibodies |
HLA association |
Comments |
References |
|
|
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|
ACA |
HLA-DRB1 |
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|
DRB1*01 |
In Hispanics and Caucasians |
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|
DRB1*04 |
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|
HLA-DQB1 |
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|
DQB1*05 |
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|
Anti-Scl-70 |
HLA-DRB1 |
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|
DRB1*1101 |
In Caucasians and African Americans |
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|
DRB1*1104 |
In Japanese |
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|
DRB1*1502 |
In Hispanics and Caucasians |
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|
HLA-DQB1 |
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|
DQB1*0301 |
[71] |
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|
DQB1*0601 |
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|
HLA-DPB1 |
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|
DPB1*1301 |
In Caucasians |
[55] |
|
|
DPB1*0901 |
In Japanese |
[136] |
|
|
Anti-PM-Scl |
HLA-DQA1*0501 |
Not seen in Japanese |
|
|
HLA-DRB1*0301 |
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|
Anti-Th/To |
HLA-DRB1*11 |
[87] |
|
|
Anti-RNAP |
HLA-DQB1*0201 ? |
||
|
No association |
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|
Anti-U1-RNP |
HLA-DR2 |
In Japanese and Caucasians |
[117] |
|
HLA-DR4 |
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|
HLA-DQw5 |
In African Americans |
[118] |
|
|
DQA1*0101 |
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|
DQB1*0501 |
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|
HLA-DQw8 |
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|
DQB1*0302 |
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|
Anti-U3-RNP/antifibrillarin antibodies |
HLA-DQB1*0604 ? |
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|
No association |
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|
|
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|
Question marks denote associations seen in one study but not confirmed elsewhere. ACA, anti-centromere antibodies; HLA, human leukocyte antigen; RNP, ribonucleoprotein. |
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|
Ho and Reveille Arthritis Res Ther 2003 5:80 doi:10.1186/ar628 |
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