Matrix metalloproteinase (MMP) inhibitor interactions. Subsites around the catalytic zinc (Zn) bind amino acids in the substrate on either side of the cleavage site. Synthetic MMP inhibitors use a zinc binding group (ZnBG) attached to modified peptides that can bind tightly to these subsites. LHS, left-hand side; P, position of residues in the peptide; RHS, right-hand side; S, subsites of the active site.
Catterall and Cawston Arthritis Res Ther 2003 5:12-24 doi:10.1186/ar604