|
Matrix metalloproteinases (MMPs) and their substrates |
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| MMP |
Enzyme |
Mr latent |
Mr active |
Known substrates |
|
|
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| MMP-1 |
Interstitial collagenase (collagenase-1) |
55,000 |
45,000 |
Collagens I, II, III, VII, VIII and X, gelatin, aggrecan, versican, proteoglycan link protein, casein, α1-proteinase inhibitor, α2-M, pregnancy zone protein, ovostatin, nidogen, MBP, proTNF, L-selectin, proMMP-2, proMMP-9 |
| MMP-2 |
Gelatinase A |
72,000 |
66,000 |
Collagens I, IV, V, VII, X, XI and XIV, gelatin, elastin, fibronectin, aggrecan, versican, proteoglycan link protein, MBP, proTNF, α1-proteinase inhibitor, proMMP-9, proMMP-13 |
| MMP-3 |
Stromelysin-1 |
57,000 |
45,000 |
Collagens III, IV, IX and X, gelatin, aggrecan, versican, perlecan, nidogen, proteoglycan link protein, fibronectin, laminin, elastin, casein, fibrinogen, antithrombin-III, α2M, ovostatin, α1-proteinase inhibitor, MBP, proTNF, proMMP-1, proMMP-7, proMMP-8, proMMP-9, proMMP-13 |
| MMP-7 |
Matrilysin-1 (PUMP-1) |
28,000 |
19,000 |
Collagens IV and X, gelatin, aggrecan, proteoglycan link protein, fibronectin, laminin, entactin, elastin, casein, transferrin, MBP, α1-proteinase inhibitor, proTNF, proMMP-1, proMMP-2, proMMP-9 |
| MMP-8 |
Neutrophil collagenase |
75,000 |
58,000 |
Collagens I, II, III, V, VII, VIII and X, gelatin, aggrecan, α1-proteinase (collagenase-2) inhibitor, α2-antiplasmin, fibronectin |
| MMP-9 |
Gelatinase B |
92,000 |
86,000 |
Collagens IV, V, VII, X and XIV, gelatin, elastin, aggrecan, versican, proteoglycan link protein, fibronectin, nidogen, α1-proteinase inhibitor, MBP, proTNF |
| MMP-10 |
Stromelysin-2 |
57,000 |
44,000 |
Collagens III, IV and V, gelatin, casein, aggrecan, elastin, proteoglycan link protein, fibronectin, proMMP-1, proMMP-8 |
| MMP-11 |
Stromelysin-3 |
51,000 |
44,000 |
α1-proteinase inhibitor |
| MMP-12 |
Macrophage metalloelastase |
54,000 |
45,000/ 22,000 |
Collagen IV, gelatin, elastin, α1-proteinase inhibitor, fibronectin, vitronectin, laminin, proTNF, MBP |
| MMP-13 |
Collagenase-3 |
60,000 |
48,000 |
Collagens I, II, III and IV, gelatin, plasminogen activator inhibitor 2, aggrecan, perlecan, tenascin |
| MMP-14 |
MT1-MMP |
66,000 |
56,000 |
Collagens I, II and III, gelatin, casein, elastin, fibronectin, laminin B chain, vitronectin, aggrecan, dermatan sulfate proteoglycan, MMP-2, MMP-13, proTNF |
| MMP-15 |
MT2-MMP |
72,000 |
60,000 |
proMMP-2, gelatin, fibronectin, tenascin, nidogen, laminin |
| MMP-16 |
MT3-MMP |
64,000 |
52,000 |
proMMP-2 |
| MMP-17 |
MT4-MMP |
57,000 |
53,000 |
|
| MMP-18 |
Xenopus collagenase |
55,000 |
42,000 |
|
| MMP-19 |
54,000 |
45,000 |
Collagen IV, gelatin, laminin, nidogen, tenascin, fibronectin, aggrecan, COMP |
|
| MMP-20 |
Enamelysin |
54,000 |
22,000 |
Amelogenin |
| MMP-21 |
XMMP (xenopus) |
70,000 |
53,000 |
|
| MMP-22 (MMP-27) |
CMMP (chicken) |
52,000 |
43,000 |
Gelatin, casein |
| MMP-23 |
CA-MMP |
? |
? |
|
| MMP-24 |
MT5-MMP |
63,000 |
45,000 |
proMMP-2, proMMP-9, gelatin |
| MMP-25 |
MT6-MMP, leukolysin |
56,000 |
Collagen IV, gelatin, fibronectin, fibrin |
|
| MMP-26 |
Matrilysin-2, endometase |
28,000 |
Collagen IV, fibronectin, fibrinogen, gelatin, α1-proteinase inhibitor, proMMP-9 |
|
| MMP-28 |
Epilysin |
59,000 (55,000) |
Casein |
|
|
α2-M, α2-macroglobulin; COMP, cartilage oligomeric matrix protein; MBP, myelin basic protein; Mr, relative molecular mass; TNF, tumour necrosis factor. | ||||
Murphy et al. Arthritis Res 2002 4(Suppl 3):S39 doi:10.1186/ar572 |
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