The role of structural genes in the pathogenesis of osteoarthritic disorders

doi:10.1186/ar595

Arthritis Res

Volume 4
Issue 6

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The role of structural genes in the pathogenesis of osteoarthritic disorders

Anthony M Reginato¹^,2 and Bjorn R Olsen¹

¹Department of Cell Biology, Harvard Medical School, Boston, MA, USA

²Department of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, MA USA

author email corresponding author email

Arthritis Res 2002, 4:337-345doi:10.1186/ar595


Published:	30 August 2002

Abstract

Osteoarthritis (OA), one of the most common age-related chronic disorders of articular cartilage, joints, and bone tissue, represents a major public health problem. Genetic studies have identified multiple gene variations associated with an increased risk of OA. These findings suggest that there is a large genetic component to OA and that the disorder belongs in the multigenetic, multifactorial class of genetic diseases. Studies of chondrodysplasias and associated hereditary OA have provided a better understanding of the role of structural genes in the maintenance and repair of articular cartilage, in the regulation of chondrocyte proliferation and gene expression, and in the pathogenesis of OA.