Email updates

Keep up to date with the latest news and content from Arthritis Research & Therapy and BioMed Central.

Review

Genetic epidemiology: Juvenile idiopathic arthritis genetics - What's new? What's next?

Wendy Thomson* and Rachelle Donn

Author Affiliations

Arthritis Research Campaign Epidemiology Unit, School of Epidemiology and Health Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK

For all author emails, please log on.

Arthritis Res 2002, 4:302-306  doi:10.1186/ar591

Published: 5 August 2002

Abstract

Studies have established the magnitude of the genetic basis of juvenile idiopathic arthritis (JIA). JIA is a complex genetic condition and the genes that influence susceptibility are actively being sought. A candidate gene approach is being used by several groups. MHC-, cytokine- and T-cell-related genes have all been positively associated with JIA. Here we review some of the latest genetic data, and discuss ways in which JIA genetic research might proceed.

Keywords:
candidate genes; cytokines; genetics; juvenile idiopathic arthritis