Figure 1.

Methotrexate-induced metabolic changes lead to increased extra-cellular adenosine. ADA = adenosine deaminase; AICAR = aminoimidazolecarboxamidoribonucleotide; AICAside = aminoimidazolecarboxamidoribonucleoside; AK = adenosine kinase; AMPDA = AMP deaminase; DHF = dihydrofolate; DHF_glu = dihydrofolate polyglutamate; ecto-5'NT = ecto-5'nucleotidase; FAICAR = formyl-AICAR; IMP = inosine monophosphate; MTX = methotrexate; MTX_glu = methotrexate polyglutamate; RFC1 = reduced folate carrier 1.