Arthritis Research & Therapy

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The potential of human regulatory T cells generated ex vivo as a treatment for lupus and other chronic inflammatory diseases

David A Horwitz*, J Dixon Gray and Song G Zheng

Arthritis Res 2002, 4:241-246 doi:10.1186/ar414

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Induction of granzyme B expression in T-cell receptor/CD28-stimulated human regulatory T cells is suppressed by inhibitors of the PI3K-mTOR pathway

Olga V Efimova, Todd W Kelley BMC Immunology 2009, 10:59 (22 November 2009)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Inhibiting the mTOR and PI3K pathways does not affect the proliferation of regulatory T cells activated via TCR/CD28, but does prevent the induction of Granzyme B, a molecule involved in the cytotoxic immunosuppression mediated by these cells.

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