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Commentary

Homing chemokines in rheumatoid arthritis

Pius Loetscher* and Bernhard Moser

Author Affiliations

Theodor-Kocher Institute, University of Bern, Switzerland

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Arthritis Res 2002, 4:233-236  doi:10.1186/ar412

Published: 31 January 2002

Abstract

In about 20% of patients with rheumatoid arthritis, B and T lymphocytes recruited into the inflamed synovium are organized into complex microstructures, which resemble secondary lymphoid organs. The development of such lymphoid aggregates with germinal centers appears to contribute to the pathogenesis of the disease. Growing evidence indicates that chemokines and their receptors control the recruitment and positioning of leukocytes as well as their organization into node-like lymphoid structures. Here, we comment on recent studies highlighting the importance of chemokines in rheumatoid arthritis, in particular of B-cell-activating chemokine-1 in lymphoid neogenesis in the inflamed synovium.

Keywords:
BCA-1; chemokine receptors; chemokines; CXCR5; ectopic follicles