Table 1

Rheumatoid arthritis autoantigens with relatively high specificity

Antigen

Sensitivity (%)

Specificity (%)

Rheumatoid factor

70–75

Also present in other autoimmune diseases,

infectious diseases and healthy individuals

Anti-perinuclear factor/anti-filaggrin/anti-cyclic citrullinated peptide

50–91

> 97

Sa

≤ 40

85–95

Heavy chain binding protein (BiP)/p68

≤ 68

> 97^*

Glucose-6-phosphate isomerase

≤ 64

> 95^*

^*Requires confirmation by further studies.

van Boekel et al. Arthritis Res 2002 4:87   doi:10.1186/ar395