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Commentary

Commentary on "Genetic linkage and transmission disequilibrium of marker haplotypes at chromosome 1q41 in human systemic lupus erythematosus", by RR Graham et al.

Anne C Barton* and Jane Worthington

Author Affiliations

Arthritis and Rheumatism Campaign Epidemiology Unit, University of Manchester, Manchester, UK

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Arthritis Res 2002, 4:84-86  doi:10.1186/ar394

Published: 19 November 2001

Abstract

Genome-wide linkage analysis studies in families with systemic lupus erythematosus (SLE) have revealed consistent evidence of linkage to several regions of the genome. In a previous issue of this journal, Graham and colleagues described their approach to following up the linkage data for one of these regions, 1q41–42. Using methods based on the transmission disequilibrium test, the region likely to harbour a SLE disease gene was refined to 2.3 Mb. This commentary discusses their approach and identifies lessons that may be applicable to the investigation of other complex diseases.

Keywords:
association; linkage; systemic lupus erythematosus; transmission disequilibrium test; whole-genome scan